Salk researchers advance sonogenetics technology for treating neurological conditions

first_imgReviewed by James Ives, M.Psych. (Editor)Oct 23 2018The emerging technology of sonogenetics–a technique where cells are controlled by sound–offers the potential to one day replace pharmaceutical drugs or invasive surgical treatments for neurological conditions like epilepsy, Parkinson’s disease or posttraumatic stress disorder.The Salk Institute scientist who pioneered the idea of using ultrasonic waves to stimulate neurons and coined the term “sonogenetics” will participate in the Defense Advanced Research Projects Agency’s ElectRx program, aiming to take his lab’s work to the next level with $750,000 in new funding.”We initiated this project about six years ago, when we first brought ultrasound into the laboratory to study a biological system,” says Salk Associate Professor Sreekanth Chalasani, the principal investigator of the grant. “We wanted to know whether ultrasound could stimulate behavior in the nematode–a simple organism whose basic neurological circuitry has similarities to our own–and, strikingly, we found that it could.”In 2012, Chalasani received a Salk Innovation Grant to explore his idea of genetically engineering neurons in the worm to respond to sound waves. He first demonstrated the technique on nematodes in 2015, showing that low-intensity ultrasound waves propagating into the worms caused a chemically sensitive molecular channel called TRP-4 to open and activate brain cells. His team then used molecular biology techniques to add the TRP-4 channel to neurons that don’t usually react to ultrasound, successfully activating them and influencing the worms’ behavior. The lab leveraged the early success of their approach into a grant from the National Institutes of Health’s (NIH) Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative to explore additional molecular channels that could be targeted with ultrasound. The team also showed the technique works in a mouse model.Related StoriesUCLA physicians find more effective method for detecting prostate cancerContinuous personnel changes are a major cause of NHS ultrasound staff shortage, shows studyNew intervention shows promise for relief of shoulder pain in wheelchair users with spinal cord injuryBefore the development of sonogenetics, scientists used a tool called optogenetics to stimulate neurons with light. While optogenetics continues to be a highly valuable tool for neuroscience research, the approach has some therapeutic limitations.”With optogenetics, you need to surgically implant some sort of probe or light-emitting device in or very near the tissue that you are targeting,” says Yusuf Tufail, a research scientist in the Chalasani lab. “But with sonogenetics, you don’t need surgery, because the genetic components that make neurons sensitive to ultrasound can be delivered via therapeutic viruses, and then the ultrasound stimulation is applied from outside the body, just like a pregnancy ultrasound.”Now, the team aims to search for additional proteins that will respond to ultrasound–but rather than activate neurons, these proteins would inhibit cells. Methods to both noninvasively inhibit as well as activate neurons have immense potential for therapies.”Sonogenetics is a very exciting way in which we could potentially treat different neurological conditions without having to invasively implant electrodes into patients,” says Corinne Lee-Kubli, a research associate in the Chalasani lab. “Parkinson’s disease, neuropathic pain, PTSD and movement disorders, such as paralysis, could theoretically all benefit from a sonogenetics approach.”With this new support, the team will build novel, custom-made instruments to develop and assess the technology.Adds Chalasani, “We are excited with the results that we have obtained. We’re excited with the prospects of this technology, which we think could revolutionize the fields of both neuroscience and medicine.”Source: read more

New nanoimmunotherapy promotes longterm acceptance of transplanted organs

first_imgAfrica Studio | ShutterstockThe development, which is described in the journal Immunity, could transform patient care and provide a solution to the problems that stand in the way of successful transplant outcomes. Related StoriesAMSBIO offers new, best-in-class CAR-T cell range for research and immunotherapyNanotechnology-based compound used to deliver hepatitis B vaccineExciting study shows how centrioles center the process of cell divisionA transplanted organ is rejected by the body when innate immune cells called myeloid cells induce T-cells to attack it. To prevent this immune response, patients must take drugs that suppress this T-cell activity, but this dampening down of the patient’s immune system leaves them vulnerable to infection and cancer. The patients also have to take more than a dozen pills every day for the remainder of their lives.Now, Ochando and colleagues have developed a nano-immunotherapy that targets myeloid cells and prevents their activation and their triggering of T-cells. The T-cells are unaffected by the therapy and maintain their usual function, but without attacking the transplanted organ. If this can be successfully translated to the clinic, this may eliminate the need for lifelong, continuous immunosuppressive medication and provide a promising solution for successful organ transplantation”Jordi Ochando, study author Instead of suppressing the effects of organ transplantation (activated T-cells), we are preventing the cause (myeloid cell activation) in a highly specific yet short-term fashion. It’s a completely different approach that can be employed to other conditions that are characterized by maladaptive trained immunity, such as autoimmune and cardiovascular diseases,”Willem Mulder, co-author.center_img In a mouse model, the authors found that 100 days after heart transplant, mice that were given the nano-immunotherapy but no standard anti-rejection therapy had accepted the transplant. All mice that did not receive either therapy rejected the transplant within ten days and all mice that received only the standard drugs rejected the transplant within 50 days.Mulder says the team hopes the new nano-immunotherapy can eventually become the standard of care for organ transplant recipients, eliminating the need for medication and further treatment.“It may increase the success rate of organ transplantation and makes it safer and easier process for patients,” he concludes.Source: Nov 7 2018Researchers at the Mount Sinai School of Medicine have developed a new nanotechnology-based immunotherapy that promotes long-term transplant acceptance in an animal model.last_img read more

Reaching Scientists Through Newsletters

first_imgThis provides valuable information on which systems and applications your potential customer is interested in; and by taking a big data approach this information can be used to provide personalized content to further increase engagement.Newsletter Marketing the Right Way Newsletter marketing is only effective if it is done the right way. Marketers should make sure that they are sending relevant content to relevant people.Several options are available to companies who want to promote their content via newsletters. The first of these is for companies to send their own in-house newsletters. While this has the benefit of costing little to carry out, it is also a limited method as the newsletter can only be sent to individuals already on the company database. This means in-house newsletters tend to have a small reach and cannot be used to connect with new potential customers. Today we tell these stories across all digital platforms to a monthly addressable audience in excess of 5 million unique individuals.Our customers come from all scientific, technological and medical sectors. Our extensive web footprint and subscriber base allows us to display a measurable return on investment to billion dollar multi-nationals and SME start-ups.From Content Creation, through targeted distribution to closing the loop with the unique AZoIntel Content Performance analytics platform, AZoNetwork now provides a highly effective Science Marketing Platform based on its own unique Marketing Science. By Stuart MilneDec 3 2018Reviewed by Ben Stibbs-Eaton Some companies may supplement their own database with purchased lists of subscribers, though we would strongly advise against this. Besides risking breaking GDPR compliance it is extremely difficult to assess the quality of purchased subscriber lists. Subscribers are also unlikely to open emails from names and accounts that they don’t recognize. If they haven’t opted into your newsletters, they’re unlikely to open your emails, meaning the content inside them will remain unseen.Sponsor a NewsletterA popular solution is to use an external newsletter provider to promote your content. It’s important to consider the quality of the newsletter subscriber base when choosing a provider. While larger newsletter providers can offer lower costs per subscriber, if the subscriber quality is low or it is not the right audience, this is a false economy as the return will not be satisfactory.The science industry is a specialized industry, and for this reason newsletter campaigns to scientists should be specialized too.AZoNetwork’s Scientific Newsletters AZoNetwork curate and run more than 20 different scientific newsletters to a highly engaged scientific audience. These newsletters are designed to help our readers keep up to date on the cutting edge of science; containing the latest news and technologies stories relevant to their field. Life Science EditionsMedical EditionsMaterials EditionsIndustry EditionsMicroscopy EditionsAnalytical Technique Editions Image Credit: maicasaa/Shutterstock.comMaking your content visible is key to building a successful content marketing strategy, but marketers need to do more to capitalize on its value. Waiting for a potential customer to stumble onto your content isn’t enough when you could be sending it directly to their inbox. Newsletter marketing is an established practice with tangible results. Research has shown that for every $1 spent on emailing marketing, companies make an average $44 return.1In addition to the fantastic ROI that newsletter marketing provides, newsletters can give older content a new lease of life. Dated articles, which are still relevant, can be recycled for use in a newsletter – resurrecting the content with new traffic.AZoInsights: Recipients are 70% more likely to share content they receive by email.2In addition, newsletter marketing provides rich levels of data compared to anonymous visits to a webpage. The information of newsletter subscribers who click through on newsletter content can be analyzed and ‘buyer journeys’ (the journey the subscriber makes through the different pages of a website) can be visualized. Tracking the Customer Journey We love telling science, technology and medical stories to people who can make a difference. Everything else follows from that. 33% of email recipients open an email based on subject line aloneHubspot We break our newsletters down by application and technology areas. Meaning only our readers who are interested in life science microscopy are going to be receiving our Life Science Microscopy edition. For this reason we have click-through rates above industry averages and extremely low unsubscribe numbers.AZoNetwork offer science and technology companies the opportunity to sponsor our newsletters, allowing your content to be featured alongside the latest science and technology stories. The newsletters are highly targeted, meaning your stories are being sent to the right people, and we’ll help you choose the content to make sure you get the click-through rate that your content deserves.Marketeers can use the opportunity to promote many different types of content such as articles, webinars, white paper downloads and more. In addition, all the click-throughs are recorded and, as we are fully GDPR compliant, we can share the contact information of any subscribers who show interest with you.At AZoNetwork we have been growing and nurturing our subscriber base from the very start, making sure we keep our subscribers engaged. In addition, our audience segmentation makes it easy to target the right audience for your application, without wasting money on subscribers who aren’t interested. If you’d like to find out more about featuring in one of our industry-specific newsletters let us know and we’ll be happy to tell you more. Sponsor a NewsletterAbout AZoNetworkHaving worked in the Advanced Ceramics industry for over a decade in the 90’s, founder, Dr. Ian Birkby recognized that engineers, designers and scientists often required educating in the potential uses and applications of Advanced Materials before they could utilize them in their products and processes.This recognition of market demand and the emerging power of the internet led to the launch of our first site, – The A to Z of Materials in 2000.Although the business has grown significantly to include a range of science, technology, medical and life science platforms, it has always stayed true to its principal aim: AZoNetwork Newsletters Related Content References and Further Reading1 – Word Stream – Email Marketing Statistics2 – Vital – Guide to Email Marketinglast_img read more

Researchers present mechanisms cellular targets involved with effects of TGFBeta 1 muscle

first_img Source: Reviewed by James Ives, M.Psych. (Editor)Dec 21 2018The innate immune system comprises of various soluble factors that provide the first line of defense against pathogens. Transforming Growth Factor type Beta 1 (TGF-β1) is one such soluble factor that also regulates skeletal muscle function, and it one of the most studied factors. TGF-Beta 1 is a potent modulator of immune and glial cell functions. It is known to have a play in to cardiac fibrosis and muscle atrophy. It also regulates the activity and function of satellite cells that inhibits myo-genesis.In this review, researchers present different types of mechanisms and cellular targets which are involved with the effects of TGF-Beta 1 muscles, such as pothological the processes like fibrosis, atrophy and inhibition of regeneration. Furthermore, the reviewers also present an update on the development of new strategies with therapeutic potential to inhibit the deleterious actions of TGF-β in skeletal muscle.last_img read more

Researchers discover mechanism which drives leukemia cell growth

first_imgReviewed by James Ives, M.Psych. (Editor)Jan 17 2019A mechanism which drives leukemia cell growth has been discovered by researchers at the University of Sussex, who believe their findings could help to inform new strategies when it comes to treating the cancer.Acute myeloid leukemia (AML) is a devastating blood cancer with around 3,000 new cases annually in the UK.Despite considerable improvement in patient survival over the last 50 years, the prognosis remains poor for many subsets of adults and children who suffer from the disease.Current chemotherapies are highly toxic, and often fail to induce a long-term cure resulting in an urgent clinical need for the design of better tolerated and highly targeted therapies that induce durable remissions.Leukemia cells are known to have an overactive level of a protein called β-catenin, which can drive cancer development. Once this protein moves into the nucleus of cells, where DNA is stored, it can assist the activation of genes important for leukemia development. The activity of β-catenin is highly dependent upon the interactions it forms with other proteins in the cell.Related StoriesMathematical model helps quantify metastatic cell behaviorNANOLIVE‘s novel CX-A defines a new standard for live cell imaging in 96 well plates for continuous organelle monitoring in cell populationsComprehensive cell atlas of the human liverUp until now, the movement of β-catenin into the nucleus of leukemia cells has been a poorly understood process in blood cells.But researchers from the University of Sussex, Bristol and Cardiff using funding from the Kay Kendall Leukaemia Fund (KKLF) and Bloodwise have now discovered a protein partner that promotes this process and therefore helps leukemia cells to grow. Their findings could lead to the development of new therapeutic strategies to treat AML.In a paper published in the journal Haematologica, Dr Rhys Morgan, Lecturer in Biomedical Science, observed that protein LEF-1 can actively control the level of β-catenin in the nucleus of myeloid leukemia cells. This is the first study to reveal such a mechanism is active in leukemia cells, and also the first to reveal β-catenin’s interaction partners in blood cells.Dr Rhys Morgan, from the University of Sussex, said: “Whilst scientists have long been aware of the involvement of β-catenin in cancer progression, drugs directly targeting the protein or its partners haven’t yet reached the clinic. From our research findings we’d suggest that pharmacological targeting of β-catenin’s movement into the nucleus, through a partner like LEF-1, could be a viable treatment strategy in leukemia.”He explained further: “This research is at a very early stage and targeting the activity of β-catenin won’t be a solution for all leukemia cases and subtypes.”However data suggests that anywhere between 20-80% of AML cases display elevated levels of this molecule which justifies further investigation in this setting.”Dr Morgan and his team are now working to further understand the biological significance of many of the new interacting proteins discovered in the study, with the belief that others could be worth targeting to inhibit β-catenin level and activity in leukemia.Source: read more

Researchers move one step closer to finding a cure for spina bifida

first_imgMar 8 2019Researchers on the path to finding a cure for spina bifida have identified specific elements in stem cell secretions as key to protecting neurons and ultimately reducing the lower-limb paralysis associated with the birth defect.Those elements are exosomes — vesicles that transfer molecules from cell to cell — and a small carbohydrate-binding protein known as galectin 1.The team will use the results to optimize the neuroprotective qualities of a stem cell treatment they developed to improve the mobility issues associated with spina bifida.Published in the Journal of the Federation of American Societies for Experimental Biology, the study was led by Aijun Wang, co-director of the UC Davis Health Surgical Bioengineering Laboratory.Related StoriesNanoparticles used to deliver CRISPR gene editing tools into the cellNew study reveals ‘clutch’ proteins responsible for putting T cell activation ‘into gear’Mother calls for protein shake regulation after daughter diesAltering the outcomes of spina bifidaUC Davis Health fetal surgeon and study co-author Diana Farmer first showed that prenatal surgery reduces neurological defects in children with spina bifida, which occurs when the spinal cord does not properly close before birth. Children with the condition experience a range of lifelong cognitive, urological, musculoskeletal and motor disabilities.Farmer and Wang, her chief collaborator, later showed that prenatal surgery combined with human placenta-derived mesenchymal stromal cells (PMSCs) improved hind limb control in lab animals and dogs with spina bifida.”We wanted to know the specific mechanisms of action of the PMSC treatment that protect neurons,” Wang said. “Our new results provide evidence that stem cell secretions containing exosomes that express galectin 1 are an important part of the therapeutic benefits and give us a path for optimizing the neuroprotective qualities of the treatment.”Hope for a cell-free treatmentThe new study also could help the researchers produce a cell-free treatment for spina bifida and other spinal cord injuries based on byproducts of stem cells rather than the stem cells themselves, according to Wang.Stem cells can heal, however they also can influence the broader immune system and treatment site, making the possibility of cell-free treatment highly attractive.”Stem cell secretions can have the same or similar healing qualities, but also are a more stable and controllable product,” Wang said. “We are excited about what we see so far and are anxious to further explore the clinical applications of this research.” Source: read more

labfolder and cubuslab merge to form Labforward

first_imgThe cubuslab products and the competences of the cubuslab team together with the strengths of labfolder pave the way for an important strategic development. A laboratory process has three basic steps: planning, execution and documentation. With labfolder, we are established in the documentation stage, where all data comes together; with the cubuslab platform and the data from laboratory devices, we simplify and increase the number of data inputs. The cubuslab founders remain in the joint company. We are enormously impressed by what the cubuslab team has achieved. We have known and appreciated each other for several years, so we are looking forward to working together in the future in addition to expanding our expertise.”Dr. Simon Bungers, CEO and Co-Founder of labfolder Labforward is currently working with leading companies in Germany, Europe, the USA and Asia to roll out these innovations internationally. The next highlight this autumn is the Beijing Conference and Exhibition on Instrumental Analysis (BCEIA) in Beijing. Labforward therefore also stands for openness and interoperability. We do not believe that closed systems will be a long-term success on the market. This means that the cubuslab box and software can also talk to other LIMS (Laboratory Information Management Systems) and ELNs and labfolder also interacts with other device platforms. What is important is that we have the expertise in both areas – in the laboratory, where the data is generated, and where the data is stored and processed”.Dr. Dominic Lütjohan, cubuslab CEO and Co-Founder Related StoriesRevolutionary gene replacement surgery restores vision in patients with retinal degenerationNew study provides increasing evidence base substantiating vaping’s harm reduction potentialAge-related risk of Alzheimer’s explained at the molecular levelThe idea of combining the competencies of both companies was born at the end of 2017: “As alumni of the Merck Accelerator Program, we gave a joint lecture at a conference organized by Merck in Dubai,” says Julian Lübke, Head of cubuslab Product and co-founder of cubuslab. “We were already joking after our presentation that we should join forces. In the following year, we worked together on so many projects that the tremendous advantages of the cooperation for both parties became obvious, and the initial joke became a serious opportunity.”cubuslab and labfolder will present the first co-developed innovation at this year’s Labvolution in Hannover, Germany: An innovative Lab Execution System (LES) that allows laboratory devices from all manufacturers to be intelligently linked into smart workflows. In contrast to many proprietary solutions, the cubuslab platform can be used to integrate, monitor and control laboratory equipment across different instrument manufacturers.center_img May 23 2019labfolder GmbH, a leading electronic laboratory notebook (ELN, Electronic Lab Notebook) provider, and cubuslab GmbH, a leading provider of a manufacturer-independent platform for the digital integration of laboratory instruments, today announced their merger. The joint company will operate under the name Labforward GmbH. Both existing branch offices – Berlin and Karlsruhe – will be retained. Source:labfolder GmbH This makes laboratory work more efficient and precise. The automatic data collection and transfer to the labfolder ELN also reduces the documentation effort enormously.”Dr. Florian Hauer, CPO and Co-Founder of labfolderlast_img read more

Study explores adolescent vaping and its association with delinquency

first_img violent delinquency including fighting at school, engaging in a gang fight, causing injury to another or carrying a weapon to school property delinquency such as stealing an item or damaging school property “Other” types of delinquency such as trespassing or running away from home Some combination of the behaviors mentioned above Reviewed by Alina Shrourou, B.Sc. (Editor)May 29 2019UTSA criminal justice professor Dylan Jackson recently published one of the first studies to explore emerging drug use in the form of adolescent vaping and its association with delinquency among 8th and 10th grade students across the nation.The Centers for Disease Control and Prevention estimate that 4.9 million middle and high school students used some type of tobacco product in 2018, up from 3.6 million in 2017. Moreover, the percentage of high school-aged children who report using e-cigarettes increased by more than 75 percent between 2017 and 2018.New legislation is targeting this dangerous trend. Earlier this year, the FDA introduced new policies to prevent adolescents from accessing flavored tobacco products, including e-cigarettes. U.S. Senators Mitch McConnell and Tim Kaine have also introduced a bipartisan bill to raise the federal smoking age to 21. The proposed bill includes the use of e-cigarettes, citing it as an “epidemic” among adolescents that has been largely overlooked.Using a nationally representative sample of 8th and 10th graders in 2017, Jackson found that adolescents who vape are at an elevated risk of engaging in criminal activities such as violence and property theft. He also found that teens who vape marijuana are at a significantly higher risk of violent and property offenses than youth who ingest marijuana through traditional means.He believes that these findings might be explained by the ability to conceal an illegal substance through the mechanism of vaping, which can reduce the likelihood of detection and apprehension among youth who vape illicit substances and thereby embolden them to engage other delinquent behaviors.Ultimately, he argues that youth who vape illicit substances such as marijuana may easily go unnoticed and/or unchallenged due to the ambiguity surrounding the substance they are vaping and the ease of concealability of vaping devices, which can look like a flash drive.Related StoriesStudy: Underweight boys and overweight girls have increased risk of depressionDiscrimination associated with compromised sleep quality in adolescentsNew study could help optimize SSRI dosing and minimize adverse effects in teensThese behaviors include four categories of delinquency: Jackson also discussed other factors related to vaping, such as youth perceptions of media messaging by product manufacturers that vaping is acceptable because it is a “healthier” option than traditional forms of smoking nicotine or marijuana. “Our hope is that this research will lead to the recognition among policymakers, practitioners, and parents that the growing trend of adolescent vaping is not simply “unhealthy” – or worse, an innocuous pastime – but that it may in fact be a red flag or an early marker of risk pertaining to violence, property offending, and other acts of misconduct.”Source:University of Texas at San AntonioJournal reference:Jackson, D.B. et al. (2019) It’s all the rage! Exploring the nuances in the link between vaping and adolescent delinquency. Journal of Criminal Justice. read more

Highfat lowcarbohydrate diet may improve brain function and memory in older adults

first_imgReviewed by James Ives, M.Psych. (Editor)Jun 28 2019In a pilot study of 14 older adults with mild cognitive problems suggestive of early Alzheimer’s disease, Johns Hopkins Medicine researchers report that a high-fat, low-carbohydrate diet may improve brain function and memory. Credit: iStock Brandt explains that, typically, the brain uses the sugar glucose — a product of carbohydrate breakdown — as a primary fuel. However, research has shown that in the early stage of Alzheimer’s disease the brain isn’t able to efficiently use glucose as an energy source. Some experts, he says, even refer to Alzheimer’s as “type 3 diabetes.”Using brain scans that show energy use, researchers have also found that ketones — chemicals formed during the breakdown of dietary fat — can be used as an alternative energy source in the brains of healthy people and those with mild cognitive impairment. For example, when a person is on a ketogenic diet, consisting of lots of fat and very few sugars and starches, the brain and body use ketones as an energy source instead of carbs.For the current study, the researchers wanted to see if people with mild cognitive impairment, often an indicator of developing Alzheimer’s disease, would benefit from a diet that forced the brain to use ketones instead of carbohydrates for fuel.After 2 1/2 years of recruitment efforts, the researchers were able to enroll 27 people in the 12-week diet study. There were a few dropouts, and so far, 14 participants have completed the study. The participants were an average age of 71. Half were women, and all but one were white.To enroll, each participant required a study partner (typically a spouse) who was responsible for ensuring that the participant followed one of two diets for the full 12 weeks. Nine participants followed a modified Atkins diet meant to restrict carbs to 20 grams per day or less, with no restriction on calories. The typical American consumes between 200 and 300 grams of carbs a day. The other five participants followed a National Institute of Aging diet, similar to the Mediterranean diet, that doesn’t restrict carbohydrates, but favors fruits, vegetables, low- or fat-free dairy, whole grains and lean proteins such as seafood or chicken.Related StoriesDiet and nutrition influence microbiome in colonic mucosaSofrito cooking technique releases healthy nutrientsLow-carb diet may reverse metabolic syndrome independent of weight lossThe participants and their partners were also asked to keep food diaries. Prior to starting the diets, those assigned to the modified Atkins diet were consuming about 158 grams of carbs per day. By week six of the diet, they had cut back to an average of 38.5 grams of carbs per day and continued dropping at nine weeks, but still short of the 20-gram target, before rising to an average of 53 grams of carbs by week 12. Participants on the National Institute of Aging diet continued to eat well over 100 grams of carbs per day.Each participant also gave urine samples at the start of the dietary regimens and every three weeks up to the end of the study, which were used to track ketone levels. More than half of the participants on the modified Atkins diet had at least some ketones in their urine by six weeks into the diet until the end; as expected, none of the participants on the National Institute of Aging control diet had any detectable ketones.Participants completed the Montreal Cognitive Assessment, the Mini-Mental State Examination and the Clinical Dementia Rating Scale at the start of the study. They were tested with a brief collection of neuropsychological memory tests before starting their diets and at six weeks and 12 weeks on the diet. At the six-week mark, the researchers found a significant improvement on memory tests, which coincided with the highest levels of ketones and lowest carb intakes.When comparing the results of tests of delayed recall — the ability to recollect something they were told or shown a few minutes earlier — those who stuck to the modified Atkins diet improved by a couple of points on average (about 15% of the total score), whereas those who didn’t follow the diet on average dropped a couple of points.The researchers say the biggest hurdle for researchers was finding people willing to make drastic changes to their eating habits and partners willing to enforce the diets. The increase in carbohydrate intake later in the study period, they said, suggests that the diet becomes unpalatable over long periods. Our early findings suggest that perhaps we don’t need to cut carbs as strictly as we initially tried. We may eventually see the same beneficial effects by adding a ketone supplement that would make the diet easier to follow. Most of all, if we can confirm these preliminary findings, using dietary changes to mitigate cognitive loss in early-stage dementia would be a real game-changer. It’s something that 400-plus experimental drugs haven’t been able to do in clinical trials.”Jason Brandt, Ph.D., professor of psychiatry and behavioral sciences and neurology at the Johns Hopkins University School of Medicine Many people would rather take a pill that causes them all kinds of nasty side effects than change their diet. Older people often say that eating the foods they love is one of the few pleasures they still enjoy in life, and they aren’t willing to give that up.”Jason Brandt Although the researchers say that finding participants willing to undertake restrictive diets for the three-month study — or partners willing to help them stick to those diets — was challenging, those who adhered to a modified Atkins diet (very low carbohydrates and extra fat) had small but measurable improvements on standardized tests of memory compared with those on a low-fat diet.The short-term results, published in the April issue of the Journal of Alzheimer’s Disease, are far from proof that the modified Atkins diet has the potential to stave off progression from mild cognitive impairment to Alzheimer’s disease or other dementias. However, they are promising enough, the researchers say, to warrant larger, longer-term studies of dietary impact on brain function. But, because Brandt’s team observed promising results even in those lax with the diet, they believe that a milder version of the high-fat/low-carb diet, perhaps in conjunction with ketone supplement drinks, is worth further study. As this study also depended on caregivers/partners to do most of the work preparing and implementing the diet, the group also wants to see if participants with less severe mild cognitive impairment can make their own dietary choices and be more apt to stick to a ketogenic diet.A standardized modified Atkins diet was created and tested at Johns Hopkins Medicine in 2002, initially to treat some seizure disorders. It’s still used very successfully for this purpose.According to the Alzheimer’s Association, about 5.8 million Americans have Alzheimer’s disease, and by 2050 the number is projected to increase to 14 million people. Source:Johns Hopkins Medicinelast_img read more

A program of therapy and coping strategies works longterm for family dementia

first_imgAfter my husband developed Alzheimer’s disease in his 50s, I spent 15 years caring for him. I was stressed and anxious throughout, feeling powerless as I watched him deteriorate, torn between prioritizing care for him, seeing my children through their teenage years and keeping an eye on my aging parents.I can see now that an intervention like START would have allayed some of my earlier anxieties by giving me appropriate practical information, advice about services, support, coping strategies, and helping me learn how to relax. Learning that it can have such long-term effects is extremely encouraging.” Shirley Nurock, a former carer who worked on the project as a liaison with the families, commented: Being a carer can be a grueling job; physically and emotionally demanding, 24 hours a day and often done purely out of love. Unfortunately, depression and anxiety can be an inevitable side effect – with 90% of carers telling us they experience stress and anxiety several times a week. Yet, for the 700,000 carers across the UK, many receive little or no support, despite NICE guidelines recommending that they do.This is a major breakthrough. We are absolutely thrilled to see this monumental evidence that START is clinically effective at reducing depression and anxiety in carers, and that the effects can still be seen six years later. This could turn the tide for carers and we would love for it to be available to all people who care for someone with dementia. Alzheimer’s Society is delighted to be supporting the further development and implementation of the START program so as many people can benefit as possible.” Taking care of a family member with dementia can be immensely difficult, particularly as their condition deteriorates and they may not appreciate their carer, so close to four in 10 family carers experience depression of anxiety.We now can offer an evidence-based approach to support their mental health in the short- and long-term, which benefits both the carer and the person they’re caring for.”Professor Gill Livingston (UCL Psychiatry), the trial’s principal investigator The START (STrAtegies for RelaTives) program is delivered by psychology graduates, trained and supervised by the research team, instead of qualified clinicians, making it easy to implement in many settings.Those delivering the therapy work with carers to develop coping strategies, supporting them to manage their own wellbeing in the long run without needing further therapy sessions. Carers received eight sessions during which there is an emphasis on planning for the future and accessing further support if needed.260 family carers took part in the trial, most of whom were caring for a family member who had only recently been diagnosed with dementia. 173 of the participants were enrolled in the START program for a two-year period and the other 87 were randomly assigned to a control group that did not receive the intervention.Six years after receiving the therapy, the carers who were in the START program had significantly fewer symptoms of depression and anxiety, and the researchers say the therapy program appeared to be both preventative and improve existing mental ill-health.Patient-related costs were close to three times lower among the families in the START program (averaging £5759 for those in START versus £16 964 in the control group in year six), which the researchers say is likely due to the carers being more able to cope and provide care for their loved one.The difference of patient-related costs did not reach statistical significance, but the researchers say this is due to the fact medical costs can be very large and variable. However, their results do strongly suggest the program is not only cost-effective, but could save money for healthcare services.Related StoriesOU Health Sciences Center awarded federal grant to enhance dementia care across OklahomaWhy women who work are less likely to develop dementiaInterdisciplinary workgroup outlines what is known and unknown about paradoxical lucidity”We’ve designed our program to keep costs low, and our results suggest it could actually result in cost savings in the longer term as dementia patients will have fewer costly medical problems if their family carer is healthy and supported,” said Professor Livingston.The START team have developed manuals to make it easier for any healthcare provider to deliver the intervention, and plan to provide accredited training at UCL in the near future. Alzheimer’s Society are supporting the team to explore different options for getting the intervention further implemented into practice, and provided funding to make cultural adaptations to widen access to minority ethnic groups. The training manuals are also available in Japanese and Spanish, and are currently being translated into Urdu.James Pickett, Head of Research at Alzheimer’s Society, said: Reviewed by James Ives, M.Psych. (Editor)Jul 12 2019A program of therapy and coping strategies for people who care for family members with dementia successfully improves the carers’ mental health for at least a six-year follow-up, finds a UCL study.Carers who took part in the program were five times less likely to have clinically significant depression than carers who were not offered the therapy, according to the findings published in the British Journal of Psychiatry.The intervention has also been shown to be cost-effective in a prior study. Source:University College Londonlast_img read more

At last a simple 3D printer for metal

first_imgA sample part printed from bulk metallic glass via the TPF-based FFF process. Credit: Elsevier Explore further Journal information: Materials Today Used to produce three-dimensional objects of almost any type, across a range of industries, including healthcare, aviation and engineering, 3-D printed materials have come of age during the last decade. Research published in the journal Materials Today demonstrates a new approach to 3-D printing to fuse metallic filaments made from metallic glass into metallic objects. Researchers use 3-D printing to create metallic glass alloys in bulk More information: Michael A. Gibson et al. 3D printing metals like thermoplastics: Fused filament fabrication of metallic glasses, Materials Today (2018). DOI: 10.1016/j.mattod.2018.07.001center_img Jan Schroers, Professor of Mechanical Engineering and Materials Science at Yale University and Desktop Metal, Inc., in Burlington, Massachusetts, USA, along with colleagues point out that 3-D printing of thermoplastics is highly advanced, but the 3-D printing of metals is still challenging and limited. The reason being that metals generally don’t exist in a state that they can be readily extruded.”We have shown theoretically in this work that we can use a range of other bulk metallic glasses and are working on making the process more practical- and commercially-usable to make 3-D printing of metals as easy and practical as the 3-D printing of thermoplastics,” said Prof. Schroers.Unlike conventional metals, bulk metallic glasses (BMGs) have a super-cooled liquid region in their thermodynamic profile and are able to undergo continuous softening upon heating—a phenomenon that is present in thermoplastics, but not conventional metals. Prof. Schroers and colleagues have thus shown that BMGs can be used in 3-D printing to generate solid, high-strength metal components under ambient conditions of the kind used in thermoplastic 3-D printing.The new work could side-step the obvious compromises in choosing thermoplastic components over metal components, or vice-versa, for a range of materials and engineering applications. Additive manufacturing of metal components has been developed previously, where a powder bed fusion process is used, however this exploits a highly-localized heating source, and then solidification of a powdered metal shaped into the desired structure. This approach is costly and complicated and requires unwieldy support structures that are not distorted by the high temperatures of the fabrication process.The approach taken by Prof. Schroers and colleagues simplifies additive manufacturing of metallic components by exploiting the unique-amongst-metals softening behavior of BMGs. Paired with this plastic like characteristics are high strength and elastic limits, high fracture toughness, and high corrosion resistance. The team has focused on a BMG made from zirconium, titanium, copper, nickel and beryllium, with alloy formula: Zr44Ti11Cu10Ni10Be25. This is a well-characterized and readily available BMG material.The team used amorphous rods of 1 millimeter (mm) diameter and of 700mm length. An extrusion temperate of 460 degrees Celsius is used and an extrusion force of 10 to 1,000 Newtons to force the softened fibers through a 0.5mm diameter nozzle. The fibers are then extruded into a 400°C stainless steel mesh wherein crystallization does not occur until at least a day has passed, before a robotically controlled extrusion can be carried out to create the desired object.When asked what challenges remain toward making BMG 3-D printing a wide-spread technique, Prof. Schroers added, “In order to widely use BMG 3-D printing, practical BMG feedstock available for a broad range of BMGs has to be made available. To use the fused filament fabrication commercially, layer-to-layer bonding has to be more reliable and consistent.” Citation: At last, a simple 3-D printer for metal (2018, September 4) retrieved 17 July 2019 from Provided by Elsevier This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Elon Musk to unveil underground tunnel transport cars

first_img Explore further Elon Musk’s Boring Company nixes one L.A. tunnel, moves onto next project © 2018 The Associated Press. All rights reserved. Tech entrepreneur Elon Musk is set to unveil an underground transportation tunnel on Tuesday that could move people faster than subways. Citation: Elon Musk to unveil underground tunnel, transport cars (2018, December 18) retrieved 17 July 2019 from Musk also plans to show off the autonomous cars that will carry people through the test tunnel, which runs about 2 miles (3.2 kilometers) under the streets of Hawthorne, California, Musk’s SpaceX headquarters. He’s also planning to unveil elevators he says will bring users’ own cars from street level to the tunnel.Tuesday’s reveal comes almost two years to the day since Musk announced on Twitter that “traffic is driving me nuts” and he was “going to build a tunnel boring machine and just start digging.””I am actually going to do this,” he added in response to initial skepticism.So began The Boring Company, tongue in cheek intentional. Since the announcement, Musk has revealed a handful of photos and videos of the tunnel’s progress.The tunnel, meant to be a “proof of concept,” is being used to help Musk and The Boring Company conduct research and development for a broader system in traffic-plagued Los Angeles and beyond.One, known as the Dugout Loop , would take Los Angeles baseball fans to Dodger Stadium from one of three subway stations. Another would take travelers from downtown Chicago to O’Hare International Airport. Both projects are in the environmental review phase.The Boring Company canceled its plans for another test tunnel on Los Angeles’ west side last month after a neighborhood coalition filed a lawsuit expressing concerns about traffic and disruptions from trucks hauling out dirt during the boring process.Musk has described a system in which vehicles would descend via elevators into tunnels and move on electrically powered platforms called skates. Up to 16 pedestrians and bicyclists could board autonomous vehicles also traveling on the skates as fast as 150 mph (240 kph).”Once fully operational (demo system rides will be free), the system will always give priority to pods for pedestrians & cyclists for less than the cost of a bus ticket,” Musk tweeted in May.For the privately funded test tunnel, Musk acquired a tunnel-boring machine that had been used in a San Francisco Bay Area project and put it down a shaft in a parking lot at the SpaceX headquarters.Musk’s vision for the underground tunnels, known as loop, is not the same as another of his transportation concepts known as hyperloop. That would involve a network of nearly airless tubes that would speed special capsules over long distances at up to 750 mph (1,200) kph), using a thin cushion of air, magnetism and solar power.The loop system is designed for shorter routes that wouldn’t require the elimination of air friction, according to The Boring Company.The company says on its website that the reason such a system hasn’t been done before is that tunnels can be as expensive as $1 billion a mile to dig. But by using the skates to transport cars, which reduces the size of the tunnels needed by about half, thus reducing the cost to build them by up to four times, the company says. In this Feb. 6, 2018, file photo, Elon Musk, founder, CEO, and lead designer of SpaceX, speaks at a news conference from the Kennedy Space Center in Cape Canaveral, Fla. Musk is set to unveil an underground transportation tunnel that could move people faster than subways. Musk plans to unveil the test tunnel Tuesday, Dec. 18, 2018, as well as the autonomous cars that will carry people through it. He’s also set to show off elevators he says will bring users’ own cars from the surface to the tunnel. (AP Photo/John Raoux, File) This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

YouTube clarifies rules on pranks as risky memes rage

first_img Citation: YouTube clarifies rules on pranks as risky memes rage (2019, January 16) retrieved 17 July 2019 from YouTube adds student plans in latest attempt to challenge Hulu, Spotify and Apple Music The company already forbid content inciting dangerous activities likely to result in serious harm.But the clarifications “make it clear that challenges like the Tide pod challenge or the Fire challenge, that can cause death and/or have caused death in some instances, have no place on YouTube,” the company said in a blog post.”We’ve made it clear that our policies prohibiting harmful and dangerous content also extend to pranks with a perceived danger of serious physical injury,” said YouTube, which like other social networks is trying to show that it is better tackling problematic content.It made clear the updated policies ban pranks that trick people into thinking they are in danger, such as fake home invasions or drive-by shootings.”YouTube is home to many beloved viral challenges and pranks, like Jimmy Kimmel’s ‘Terrible Christmas Presents’ prank or the water bottle flip challenge,” said YouTube, owned by Google’s parent Alphabet.”That said, we’ve always had policies to make sure what’s funny doesn’t cross the line into also being harmful or dangerous.”While playful or goofy challenges or pranks have become raging trends online, with video shared at YouTube or Facebook, some “memes” have put people in jeopardy.A “Fire Challenge” dared people to put flammable liquid on their bodies then ignite it, while a “Tide Pod Challenge” involved people, typically teens, biting or chewing the encapsulated candy-colored laundry detergent.A “Bird Box” thriller released on Netflix a month ago inspired a challenge for people to do things blindfolded, mimicking characters in the original streaming film.A US teenager over the weekend crashed while driving with her eyes covered, taking part in a challenge inspired by the hit Netflix show, according to media reports.YouTube policy also bans pranks that cause children trauma, for example the fake death of a parent or severe abandonment, according to the firm.Accounts that post videos violating policies on pranks will get a “strike” that will limit some features such as live streaming.A second strike within three months will result in even more limited use of YouTube, while accounts getting three strikes in that time period will be terminated. © 2019 AFP YouTube on Tuesday clarified rules against posting videos of dangerous pranks, as risky “challenges” prompt people to video themselves doing things like biting into laundry soap or driving blindfolded.center_img Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. YouTube made clear that its updated policies ban pranks that trick people into thinking they are in dangerlast_img read more

Ethiopian 737 pilots followed Boeing guidelines before crash WSJ

first_img The airliner went down soon after taking off on March 10, killing 157 people in the second deadly crash of a 737 MAX aircraft in less than five months, forcing a worldwide grounding of the model.The first—a Lion Air crash in Indonesia that killed 189 people in October—led to Boeing issuing a bulletin reminding operators of emergency guidelines to override a specially developed anti-stall system on MAX planes.The pilots trying to regain control of the Ethiopian jet at first followed those procedures to switch off the Maneuvering Characteristics Augmentation System (MCAS) but failed to recover control, the WSJ said, citing people briefed on the crash investigation’s preliminary findings.They then switched the system back as they tried to find other ways to control the jet before it crashed, the newspaper added. Its sources said “the latest details are based on data downloaded from the plane’s black-box recorders”.The preliminary report on the accident will likely be issued this week, the Ethiopian government has said. Explore further The pilots of the Ethiopian Airlines Boeing 737 MAX plane that crashed last month initially took the emergency steps outlined by the manufacturer but still could not regain control, The Wall Street Journal reported Wednesday. Boeing’s 737 MAX airliners were grounded worldwide after two deadly crashes in less than five months © 2019 AFP Ethiopian Airlines crash: What is the MCAS system on the Boeing 737 Max 8?center_img Citation: Ethiopian 737 pilots followed Boeing guidelines before crash: WSJ (2019, April 3) retrieved 17 July 2019 from The MCAS is believed to have been a key factor in both 737 MAX crashes. It is designed to automatically lower the aircraft’s nose if it detects a stall or loss of airspeed.Before it crashed, the pilots of the Lion Air 737 MAX struggled to control it as the MCAS repeatedly pushed the plane’s nose down, according to its flight data recorder.Both the Lion Air and Ethiopian planes—MAX 8 models—reportedly experienced erratic steep climbs and descents, as well as fluctuating airspeeds, before crashing shortly after takeoff.Ethiopia has said there were “clear similarities” in the two crashes.Boeing last week gathered hundreds of pilots and reporters for a presentation on proposed MCAS changes—including the system no longer repeatedly making corrections when pilots try to regain control.The company is anxious to win approval for a remedy that could get the planes back in the air.But the US Federation Aviation Administration (FAA), which faced harsh questioning last week at a congressional hearing regarding its oversight of Boeing, said it expected the plane maker to submit the proposed fix “over the coming weeks” after it undertakes additional work. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Graphic on how 737 MAX 8 planes are fitted with the MCAS system designed to prevent engine stalls, plus the fix to the system proposed by Boeing.last_img read more

Former Pakistani PM Abbasi arrested antigraft agency

first_imgPakistan’s Prime Minister Shahid Khaqan Abbasi arrives to attend The Queen’s Dinner during The Commonwealth Heads of Government Meeting (CHOGM), at Buckingham Palace in London on April 19, 2018. Daniel Leal-Olivas/Pool via ReutersISLAMABAD (Reuters) – Pakistan’s anti-corruption agency arrested a former prime minister, Shahid Khaqan Abbasi, on Thursday, a spokesman for the agency, the National Accountability Board (NAB), said. He gave no details on the grounds for the arrest but a copy of the arrest warrant shared by Abbasi’s PML-N party, indicated that he was accused of “corruption and corrupt practices”. Abbasi, who served for less than a year following the resignation of former premier Nawaz Sharif in 2017, was arrested while on his way to a news conference in the eastern city of Lahore. “They said they were from the NAB and took away Shahid Khaqan Abbasi with them,” Ahsan Iqbal, a senior PML-N parliamentarian told a television station. Last year, the NAB ordered an inquiry into both Abbasi and Sharif over a liquefied natural gas terminal project. Sharif is serving a seven-year sentence after being convicted in a separate corruption case. Reporting by Asif Shahzad and James Mackenzie; Editing by Kim Coghill, Robert BirselOur Standards:The Thomson Reuters Trust Principles.last_img read more

Asylum seekers anxiously cross into US as new policy kicks in

first_imgCIUDAD JUAREZ, Mexico (Reuters) – As a new Trump administration policy aimed at making almost all migrants ineligible for asylum at the U.S. southern border spread fear this week, those at the front of the line in Mexican border cities found the gates to the United States were still open, though they will face a much higher bar to stay. A U.S. Customs and Border Protection officer inspects documents from a Honduran migrant seeking asylum at Paso del Norte International border bridge, in this picture taken from Ciudad Juarez, Mexico July 17, 2019. REUTERS/Daniel BecerrilAs the policy went into effect on Tuesday, migrants in Ciudad Juarez and other Mexican border towns were cautiously optimistic: U.S. officials were still moving down the list of asylum seekers, calling migrants to cross the bridge into the United States and apply. The rule requires asylum-seekers who travel through a third country en route to the United States to first pursue safe-haven there, precluding claims for the thousands who travel from Central American countries through Mexico on their way to the U.S. border. However, Trump’s latest crackdown on immigration ahead of his 2020 re-election bid does not change the way asylum seekers are initially processed at the border, the Department of Homeland Security confirmed on Wednesday. “Aliens subject to the third-country-transit asylum bar will be processed through existing procedures,” a DHS spokeswoman who asked not to be named told Reuters. Migrants could still be granted interviews with U.S. asylum officers or face hearings in front of a U.S. immigration judge but the bar will be much higher for their claims to prosper. Human rights groups including the American Civil Liberties Union have sued to block the measure, saying it violates U.S. asylum obligations and forces people to remain in countries “rife with danger.” Mexican officials on Tuesday called numbers from the list of several thousand people waiting to apply for asylum in Ciudad Juarez, which borders El Paso, Texas. Ten people were called and crossed over to the United States on Tuesday morning, and another 10 followed in the afternoon, Ciudad Juarez human rights director Rogelio Pinal said. Some 750 miles away in Tijuana, migrants were called from the list for interviews in San Diego, California, on Tuesday, according to a Reuters witness. “WHAT WOULD YOU ADVISE?” Karina Reyes, a 34-year-old from Cuba, paced anxiously outside an immigration office in Ciudad Juarez on Tuesday morning, waiting to see whether she would finally get the chance to seek asylum. Her journey began in October, when she flew from Cuba to Guyana, which has loose visa requirements for those from the Communist-run island, and slowly made her way north. When she reached Ciudad Juarez in April, she faced a three-month wait to apply for protection in the United States. “After waiting for so long, we want it to be worth it,” Reyes said between swigs of Diet Coke, saying she had been too nervous to sleep the night before. Minutes later, she was among the first to be summoned from Ciudad Juarez to the Customs and Border Protection offices across the bridge since the rule came into effect. Some 10,000 people are waiting in Mexican border towns to make asylum claims, the result of a U.S. practice dubbed “metering” that limits the number of asylum claims at ports of entry per day. Many other asylum seekers cross illegally between ports of entry and hand themselves in to border officials. Slideshow (9 Images)News of the policy sparked panic among migrants. In theory, more people are expected to be deported more quickly to their home countries as a result of the new rule. On Monday night, in the final hours before the new policy came into effect, some migrants considered making a last-ditch attempt to reach the United States, Pinal said. A steady stream of migrants arrived at the bridge to the United States throughout the evening, mulling whether to cross as a group and ask U.S. officials for asylum, said Pinal, who was at the scene. One young woman, a migrant from Cuba, asked Pinal a question that he said stopped him in his tracks. “If you were my father, what would you advise me to do?” the woman said through tears, as Pinal recalled. The woman was in a precarious position. Her husband had reached the United States ahead of her and she had no one in Mexico to help her. Pinal said he advised the woman to try her luck on the bridge – for what might be her last chance at lodging an asylum claim. The woman heeded his advice but soon turned back, saying that U.S. officials told her that the long list of migrants waiting in Ciudad Juarez would still get their chance to make a claim, Pinal said.   Most of the 40 to 50 migrants who Pinal and other officials counselled at the bridge made the same decision, opting to wait in Mexico. They are likely to face a tougher bar as a result. Though he does not know how the process will play out, Pinal said he was reassured that U.S. officials continued moving down the list on Tuesday. “I breathed a big sigh of relief,” he said. Reporting by Julie Love; Additional reporting by Mica Rosenberg in Washington, Kristina Cooke in San Francisco and Lizbeth Diaz in Tijuana; Editing by Frank Jack Daniel and Leslie AdlerOur Standards:The Thomson Reuters Trust Principles.last_img read more

New Orleans Braces for Intense Floods As Tropical Storm Barry Rolls In

first_img 5 Things Hurricane Sandy Changed for Good New Orleans is bracing for a tropical storm that is expected to hit tonight or tomorrow, bringing with it chances of severe flooding. Tropical Storm Barry is slowly moving west-northwestward toward the southeastern coast of Louisiana, according to an advisory from the National Oceanic and Atmospheric Administration. The storm’s center is expected to hit the southeastern coast of Louisiana, including New Orleans, tonight or Saturday (July 13) and then continue on to the lower Mississippi Valley on Sunday. It will bring “dangerous storm surge, heavy rains, and wind conditions,” across the north-central Gulf Coast, according to NOAA. (A storm surge means that there is a danger of life-threatening floods from rising water moving inland from the coastline, NOAA officials wrote.) [Aftermath of a Storm: Images from Hurricane Katrina]Headbutting Tiny Worms Are Really, Really LoudThis rapid strike produces a loud ‘pop’ comparable to those made by snapping shrimps, one of the most intense biological sounds measured at sea.Your Recommended PlaylistVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9接下来播放Why Is It ‘Snowing’ Salt in the Dead Sea?01:53 facebook twitter 发邮件 reddit 链接已复制直播00:0000:3500:35  They expect the storm will bring “dangerous, life-threatening flooding,” with 10 to 20 inches (25 to 50 centimeters) of water accumulation in southeast Louisiana and southwest Mississippi. Louisiana is currently under a federal declaration of emergency. Currently, maximum winds remain around 50 mph (85 km/hr). But there is a chance that Tropical Storm Barry will intensify and turn into a hurricane — once winds hit 74 mph (119 km/h) — tonight or early Saturday when its center strikes the Louisiana coast, according to NOAA. Some of New Orleans sits below sea level, as if at the bottom of a bowl, and is thus prone to flooding. Fourteen years earlier, Hurricane Katrina brought flooding that devastated the area. In the years following, an extensive hurricane protection system of levees and pumps was put in place, but it isn’t yet complete, according to the AP. The pumping system is working; it’s just unclear if it can pump out water faster than Barry will dump it onto the low-lying area, New Orleans Mayor LaToya Cantrell told the AP. What’s more, the Mississippi River is already at a high level from heavy rain and snowmelt; the additional water from the storm could lead to dangerous flooding, Louisiana Gov. John Bel Edwards told the AP. A History of Destruction: 8 Great Hurricanes Originally published on Live Taboolaby TaboolaSponsored LinksSponsored LinksPromoted LinksPromoted LinksYou May LikeVikings: Free Online GamePlay this for 1 minute and see why everyone is addictedVikings: Free Online GameUndoKelley Blue Book2019 Lexus Vehicles Worth Buying for Their Resale ValueKelley Blue BookUndoGundry MD SupplementsTop Cardiologist: This One Thing Will Properly Flush Out Your BowelsGundry MD SupplementsUndoTruthFinder People Search SubscriptionOne Thing All Liars Have in Common, Brace YourselfTruthFinder People Search SubscriptionUndoAncestryThe Story Behind Your Last Name Will Surprise YouAncestryUndoClassmatesSearch For Any High School Yearbook, It’s Free.ClassmatesUndo Hurricane Katrina History and Numbers (Infographic)last_img read more

YSR Congress calls bandh to protest denial of Special Category StatusYSR Congress

first_imgAndhra Pradesh SHARE SHARE EMAIL COMMENT Published on SHARE July 23, 2018center_img YSR Congress President YS Jaganmohan Reddy   –  THE HINDU Andhra Pradesh’s principal Opposition party, the YSR Congress, has called for a Statewide bandh on Tuesday, in protest against the Centre’s decision to deny Special Category Status (SCS) to the State.The YSRC is also protesting the statements made by Prime Minister Narendra Modi and other BJP leaders in the Lok Sabha last Friday, during the debate on the no-confidence motion against the NDA government.YSR Congress chief YS Jaganmohan Reddy appealed to the public and political parties of the State to extend support to the bandh, so that the Centre is alive to the gravity of the issue and to the sentiments of the people of Andhra Pradesh.Reddy said Modi’s statement in the Lok Sabha had made it clear that it was Chief Minister N Chandrababu Naidu who had first accepted the special assistance package in lieu of the SCS and had then done a volte-face on issue. He said the Chief Minister, who is also the President of the ruling Telugu Desam Party, had had no business in thus sacrificing the interests of the State, and accused him of being indifferent to the demand for SCS from the beginning.However, the BJP should not deny the State the “promised” SCS, citing “the U-turn of the Chief Minister” on the issue as a pretext. The BJP should do the “right thing” and honour the promise of former prime minister Manmohan Singh, who had assured SCS in the Rajya Sabha at the time of bifurcation in 2014. He also reminded the BJP leaders that the party had included the SCS issue in its election manifesto during 2014, and therefore the commitment made to the people of the State should be honoured, “regardless of the attitude of the Chief Minister”.The ruling TDP leaders have been accusing YSR Congress of “opportunistic politics” and of being in league with the BJP. YSRC members of the Lok Sabha had quit the Lok Sabha protesting the denial of SCS, and had therefore not participated in the no-confidence motion on Friday. Protest COMMENTSlast_img read more

MeToo Women activists welcome Akbars resignation

first_imgPublished on COMMENT Women activists on Wednesday welcomed the resignation of Minister of State for External Affairs M J Akbar, terming it a victory of the #MeToo movement in India, and asserted that the determination and courage of about 20 women journalists “belatedly forced” the Union minister to step down. Akbar stepped down on Wednesday following a spate of allegations of sexual harassment during his days as editor of several publications. In a brief statement, Akbar said he had decided to seek justice in a court of law in his personal capacity. Kavita Krishnan, Secretary of the All India Progressive Women’s Association, said it was the determination and courage of 20 women journalists who came forward to expose Akbar that has “belatedly” forced him to resign. “PM (Narendra) Modi’s silence and tacit support for Akbar so far would have continued had it not been for the steady flood of women who refused to be deterred by the defamation case,” Krishnan told PTI. Women rights activist Ranajan Kumari said Akbar should be ashamed that he did not resign earlier and that he was still fighting against the woman who called him out. Activist Mariam Dhawale said it was a victory of the women’s movement and Akbar’s resignation was “long due”. “He should stop the terror tactics he is using to intimidate women who came out against him,” Dhawale said. Over the last fortnight, about 20 women have come forward to narrate their experiences of alleged sexual harassment at the hands of Akbar. On Tuesday, around 19 women journalists, who have worked with ‘The Asian Age’ newspaper, had come out in support of their colleague Priya Ramani who has accused Akbar of sexual harassment, a joint statement issued by them had said. The journalists had urged the court to hear their testimonies against Akbar, claiming that some of them suffered sexual harassment by the minister and others have been witness to it. crime The raging #MeTooIndia maelstrom politics RELATED #MeToo impact: MJ Akbar resigns from cabinet October 17, 2018 SHARE SHARE EMAIL ‘MeToo will not be resolved unless both men and women come forward’ SHARE COMMENTSlast_img read more

CBI vs CBI CVC submits preliminary probe report to Supreme Court

first_imgNovember 12, 2018 Asthana bribery case: Delhi HC’s status quo order extended till Nov 14 File Photo of CBI Director Alok Kumar Verma.   –  PTI Asthana bribery case: CBI DSP, middleman sent to judicial custody COMMENT Published on CBI Director appears before CVC corruption & bribery COMMENTScenter_img Below the line: Twists and turns at CBI inquiry Case to be heard on November 16 The Central Vigilance Commission (CVC) on Monday filed in the Supreme Court its preliminary enquiry report, in a sealed cover, about CBI director Alok Kumar Verma who has been divested of his duties and sent on leave in view of allegations of corruption against him.The allegations have been levelled against Verma by his deputy Rakesh Asthana, Special Director at the agency, against whom an FIR has been lodged by the CBI on graft charges. Asthana was also sent on leave by the Centre.Acting CBI director M Nageswara Rao also filed in a sealed cover the decisions taken by him from October 23-26.A bench of Chief Justice Ranjan Gogoi and Justice Sanjay Kishan Kaul took both the reports on record and fixed the matter for further hearing on November 16.The CVC and Rao placed three copies of their reports in compliance with the October 26 order. “Report of the Central Vigilance Commission (CVC) with regard to the preliminary enquiry held in respect of the petitioner — Alok Kumar Verma—in sealed cover, has been submitted in Court on Monday by Tushar Mehta, Solicitor General,” the bench said. Similarly, the apex court noted in its order that the report of the orders passed by the Acting Director was filed in sealed cover, in terms of the earlier order of the Court dated October 26, 2018 by Additional Solicitor General P S Narasimha. “Both the aforesaid reports are taken on record. All the matters will be considered on Friday next, i.e., November 16, 2018,” the bench said.On October 26, the top court had appointed Justice Patnaik to supervise the ongoing inquiry of CVC against Verma. The apex court had issued notices to the Centre and the CVC seeking their replies on Verma’s petition challenging the government’s decision to divest him of his powers as CBI chief and sending him on leave. It had also set a deadline of two weeks for the CVC to complete the preliminary inquiry against the CBI director. It had barred Rao from taking any major policy decision but granted him liberty to perform routine tasks that are essential to keep the CBI functional. It had said that a list of all the decisions taken by Rao since October 23 including decisions with regard to transfer of investigations, change of investigating officer(s) etc will be furnished to the court in a sealed cover on or before November 12, 2018, whereafter orders as would be appropriate will be passed by the court.Mehta had said that the CVC has been conducting an inquiry into the allegations made in the August 24 note/letter of the Cabinet Secretary with regard to Verma.Besides the plea filed by Verma, the court is also seized of the PIL filed by NGO Common Cause, which has sought a probe by special investigation team against CBI officers including Asthana, and had issued notices to the Centre, CBI, CVC, Asthana, Verma and Rao asking them to respond to it by November 12.Asthana has also moved the apex court with a separate petition in the matter and has sought removal of Verma from the post of CBI Director.On November 4, Congress leader Mallikarjun Kharge had moved the top court contending that divesting Verma of his statutory powers and functions is “completely illegal and arbitrary”. In an interlocutory application filed in the pending petition, Kharge, who is also a member of the three-member selection committee which appoints the CBI director, said that “as a concerned stakeholder he brings to the attention of the court the brazen and illegal actions” of the political executive in interfering with the independent functioning of the CBI director. SC directs Hyd Police to provide security to complainant against Rakesh Asthana RELATED SHARE SHARE EMAIL SHARElast_img read more